Image Caption: CRISPR-Cas9 library identified XPR1 as a potential gene regulating autophagy. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative ...

“The implication here is that if you inhibit autophagy you'd make this less likely to happen, i.e. when you kill cancer cells they would stay dead,” Andrew Thorburn, the senior author of the study and ...

Hdy-7 directly binds to TrxR1/2, triggering ROS accumulation and p53 activation. Activated p53 negatively regulates mTORC1 signaling, which is one of the major kinases responsible for the ...

Mitochondria are central hubs for cellular stress adaptation, with their function integrated with both apoptosis and autophagy pathways that determine cell fate. Alterations in mitochondrial ...

Mucin 16–Directed Therapy in Pediatric Sarcomas: Case Evidence of Ubamatamab Efficacy in Epithelioid Sarcoma and Its Implications for Other Sarcoma Subtypes Eligible patients had metastatic PDAC and ...

Autophagy, derived from a Greek word, the "self-eating" nature refers to an interesting cellular process as part of the body's own recycling mechanism for cellular damage or components that have no ...

When autophagy faltered in these pre cancer cells, unwanted protein molecules began to build up and stick together. The ...