As DNA damage caused by these agents is repaired by the base excision repair (BER) pathway, we hypothesized that single-nucleotide polymorphisms (SNPs) in BER pathway will be associated with GVHD ...

A significant proportion of human cancers overexpress DNA polymerase beta (Pol β), the major DNA polymerase involved in base excision repair. The underlying mechanism and biological consequences ...

Pharmacokinetic profile of the base-excision repair inhibitor methoxyamine-HCl (TRC102; MX) given as an one-hour intravenous infusion with temozolomide (TMZ) in the first-in-human phase I clinical ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 22 (Nov. 15, 1992), pp. 11031-11035 (5 pages) To determine whether base-to-base variations in the rate of ...

2576 Background: TRC102 is a small-molecule inhibitor of base-excision repair (BER) that is nearly completely bioavailable after oral administration. TRC102 covalently binds to apurinic/apyrimidinic ...

Base excision repair (BER) is a mechanism that helps protect cells from erroneous DNA by repairing damage throughout the cell cycle.

Without natural DNA repair processes we wouldn’t be here. This year’s Nobel Prize winners in Chemistry helped us crack how it all works.