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One of the hottest research tools these days within the academic, biotech, and pharma communities is DNA microarrays. The concept morphed from the now-classical Southern blotting procedure into ...
The DNA copy that is made, called complementary DNA (cDNA), is then applied to the microarray. The cDNA binds to complementary base pairs in each of the spots on the array, a process known as ...
DNA microarrays (cDNA or oligos) have become commonplace and instrumentation is available to automate the workflow process of production, hybridization, and image analysis.
DNA microarrays can be used to measure the expression patterns of thousands of genes in parallel, generating clues to gene function that can help to identify appropriate targets for therapeutic ...
The probe selection procedure for a standard microarray design targeting all yeast transcripts can be completed in 1 h.
Researchers in Canada have combined DNA microarrays with microfluidic devices, which are used for the precise control of liquids at the nanoscale.
These reactions also label the genes with fluorescent dyes. Finally, the researchers add the twice-amplified DNA to the second microarray chip labeled with DNA sequences of the known engineered genes.
image: DNA microarrays can be easily interrogated with only the naked eye using a new electrostatic imaging technique developed in the laboratory of Jay Groves, a chemist with Berkeley Lab, UC ...