To many working biologists, DNA-modifying enzymes are tools, not unlike a pair of molecule-sized scissors. To Dr. Barry Stoddard, a professor in the Basic Sciences division at Fred Hutch, these ...

They are enzymes whose activity is influenced by the presence or absence of methyl groups on DNA with a specific target sequence. Though these systems have evolved to protect bacteria against DNA from ...

Pin-point, a new base-editing system that uses RNA aptamers to localize DNA modifying effector enzymes at genome targets is adept in performing point-mutation edits and can enhance the therapeutic ...

The researchers observed that cellular respiratory enzymes, a major source of reactive oxygen species, relocated from the mitochondria to the nucleus in response to DNA damage.

ENZYMES that repair DNA may check for mutations by sending electrons along sections of the strand, in much the same way that electricians test for faults in circuits. The mechanism might explain ...