The team succeeded in simulating the time course of transitions in the 3D structure of the GPCRs during the process of signal transduction across the cell membrane.

Collaborative Research Centre (CRC) 1423, “Structural Dynamics of GPCR Activation and Signal Transduction”, led by biochemists Professor Annette Beck-Sickinger and Professor Torsten ...

Moreover, as negative regulators of GPCR signal transduction, the RGS proteins are intriguing potential drug targets, since their inhibition should lead to prolonged signaling from G proteins ...

The canonical view of GPCRs is that they sit on the cell membrane where they activate a variety of reactions, including an enzyme called extracellular-signal-regulated kinase (ERK), which triggers ...

"Moreover, mitochondria have another capacity that qualifies them as organelles for signal transduction: they are mobile and can dock onto motor proteins in the cell." ...

Given their role in modulating GPCR signal transduction (Figure 1), it is not surprising that RGS proteins have been implicated as potential drug targets for diverse therapeutic areas, including ...