The University of California, Riverside, discovery can be used for structure-based drug design against cancers and lead to a better understanding of how m6A, a modification associated with ...

Scientists crack structure of enzyme complex linked to cancer Study offers important information for understanding 'de novo DNA methlylation' Date: February 7, 2018 Source: University of ...

Part of the minichromosome maintenance protein (MCM) family, MCM8/9 is directly linked to ovarian insufficiency, infertility and cancers including ovarian, testicular and colon cancers, yet little ...

For the first time ever, the study linked both the low-energy as well as the much rarer high-energy state of enzymes to their function, said lead author Brandeis biophysicist Dorothee Kern, who is ...

MCM8/9 is linked to infertility and several cancers including ovarian cancer, testicular cancer and colon cancer. Now that the structure has been uncovered, the researchers hope this will help them ...

The researchers plan to continue investigating the structure and function of these enzymes. Their next steps include exploring possible ways of inhibiting the enzymes in scenarios where they are ...

A research team at the University of California, Riverside, has discovered the structure of a novel RNA-modifying enzyme, ZCCHC4, and identified the mechanism that controls how this enzyme ...

Their findings further indicate that the metabolic changes brought about by the AMPK enzyme result in distinct growth advantages to prostate cancer cells.

Controlling local protein structure as a way to regulate enzyme function allosterically is a new concept, and its discovery is “a significant breakthrough,” comments Magnus Wolf-Watz, a ...