The hippocampus is an important brain region known to support various cognitive (i.e., mental) processes, including the encoding and retrieval of memories, learning, decision-making and the regulation ...

UCSF scientists have used a high-throughput CRISPR-based technique to rapidly map the functions of nearly 500 genes in human cells, many of them never before studied in detail.

The research team led by Itakura gained new knowledge of the functions that human cells have for maintaining homeostasis through experiments in petri dishes.

Yeast cells are widely used to study G protein-coupled receptors (GPCRs), a large group of cell surface proteins in humans. However, several of these proteins lose their function when introduced ...

Metformin boosts human oligodendrocyte differentiation and myelination across stem-cell, organoid, and chimera models. The study links these effects to mitochondrial metabolic shifts, supporting its ...

Miniature models of the brain have revealed a "previously unappreciated" role of microglia, a type of cell found within the ...

Transcriptional profiling of cell division and DNA damage We set out to identify cell-cycle–regulated transcripts in human cells on a genome-wide scale using high-density oligonucleotide arrays.

Thousands of previously “invisible” microproteins—tiny chains of fewer than 100 amino acids—can profoundly change human ...

A high-resolution spatial map of the human hypothalamus makes it possible to identify specific cells, determine their exact location and analyze their neighboring cells. The cell atlas, called ...