The protein produced by the MYC oncogene is a well-known foe in the oncology world. Its presence is associated with treatment-resistant cancer cells, which grow uncontrollably and evade the immune ...
Transcription factors must find their target sites within 6 × 10 9 base pairs of human genomic DNA and must discriminate against spurious consensus elements. In some instances, selectivity is ...
In healthy cells, the protein MYC helps guide the process of transcription, in which genetic information is converted from DNA into RNA and, eventually, into proteins. However, the shapeless protein ...
The MYC oncogene family plays an important role in neoplastic disease, and has been extensively studied over decades. Evidence showing the N-terminal and C-terminal regions of MYC can function as a ...
Novel Treatment Targets in Sarcoma: More Than Just the GIST MYC has proven to be a highly potent oncoprotein when it is overexpressed, but is also a pleiotropic transcription factor essential for ...
Meet MYC, the shapeless protein responsible for making the majority of human cancer cases worse. Researchers have found a way to rein it in, offering hope for a new era of treatments. Meet MYC, the ...
Five-year follow-up data from the global, phase 2 JULIET (NCT02445248)trial, which evaluated the chimeric antigen receptor (CAR)T-cell therapy tisagenlecleucel (tisa-cel; Kymriah) in patients with ...
Dublin, Dec. 23, 2021 (GLOBE NEWSWIRE) -- The "Proto Oncogene Protein C-MYC Inhibitors - Pipeline Insight, 2021" drug pipelines has been added to ResearchAndMarkets.com's offering. This report ...
Sperm – in theory, you only need one good one to get the job done. Nevertheless, the average pair of human testicles is estimated to crank out about a trillion of these little cells over a lifetime, ...
The c-Myc oncoprotein is frequently overexpressed in human cancers and is essential for cancer cell proliferation. The dysregulation of ubiquitin-proteasome-mediated degradation is one of the ...
The growth protein, MYC, was consistently found with RBM42, which spurs MYC production, in human pancreatic tumors. Above, microscopy for MYC (red) and RBM42 (green) in a representative pancreatic ...
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