In those with glaucoma or age-related vision loss, gene expression patterns and electrical signals in optic nerve cells increased to levels normally seen in young, healthy mice.

High expression of short gene appears to contribute to destructive eye pressures in glaucoma Date: August 15, 2016 Source: Medical College of Georgia at Augusta University Summary: Too much of a ...

Gene editing could be used to treat millions of glaucoma patients. Glaucoma is a leading cause of blindness, characterized by high pressure inside the eye. Patients often rely on daily eye drops ...

Researchers have developed novel promoters that drive strong and specific gene expression in rod and cone photoreceptors in mid-to-late stages of disease, potentially offering new and improved options ...

Using a method that involved the clustering of samples that showed similarity in expression profiles, researchers were able to identify molecular signatures of early events in glaucoma progression ...

In glaucoma, the optic nerve that connects the eye to the brain is progressively damaged, often in association with elevated pressure inside the eye. Researchers used gene therapy to regenerate ...

In the image, GFP expression (yellow) is observed broadly distributed in all parts of retinal ganglion cells, suggesting the viral delivery system could deliver therapeutic genes.

The AhUBQ4 promoter enables strong and stable gene expression and boosts CRISPR/Cas9 editing efficiency in peanut, outperforming traditional viral promoters like CaMV 35S.

There are several anatomical and cellular barriers that make gene therapy for glaucoma particularly challenging. Can nanocarriers effectively deliver therapeutic genes to retinal cells?

In exfoliation glaucoma, a protein dandruff clogs the outflow pathway for the fluid in our eyes. Scientists have evidence that variants of the same gene that enables us to make connective tissue ...