Origin-recognition complex (ORC) plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports.

A team of researchers unveils a novel, key aspect of enhancer-mediated regulation of gene expression and proposes a mechanism that explains the tight connection between gene enhancers and promoters.

Gene expression is regulated by an intricate interplay of many factors at different levels. To understand how the currently observed expression patterns have evolved, we need to understand the ...

A new study has found that ORC plays a broad, unexpected role in regulating human cell gene expression and chromatin ...

This article aims to describe the regulatory mechanisms that control gene expression in both eukaryotes and prokaryotes.

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease.

A research group has discovered the logic that controls gene regulation in human cells. In the future, this new knowledge can be applied to, for example, investigating cancers and other genetic ...

Because the exon junction complexes play such a major role in normal gene expression, leaving them out could have effects that scientists hadn’t been accounting for. “When people develop reporters for ...

A Yale research team has created a new computer tool that can pinpoint when exactly genes turn on and off over time during ...

“This is the first detailed study of how and where ORC regulates epigenetics and gene expression in human cells,” said Anindya Dutta, Ph.D., leader of the study and chair of the University of Alabama ...