either through direct mutation of the splice-site signals or through disruption of other components of the splicing pathway (Wang & Cooper 2007). Therefore, understanding what information in pre ...

It will be useful to determine if other deletions exist in families in which Δ9 has been confirmed through RT–PCR or immunoblot experiments but in which splice-site mutations have not been found 3.

This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...

Detailed map of the spliceosome is being made publicly available to help researchers pinpoint exactly where splicing errors ...

Chronic liver disease (CLD) is a growing global health challenge, accounting for millions of deaths each year. Its major ...

Childhood or young adult onset patients usually with acromegaly can also have mutations in the AIP gene without a known family history of pituitary adenoma. DNA (Deoxyribose Nucleic Acid) is the ...

GluK1-1 splice variant alters the gating properties of kainate receptors, providing crucial insights into receptor modulation by auxiliary proteins and advancing the understanding of synaptic ...

How could a "bad" gene-- the mutation that causes the sometimes lethal sickle cell disease -- also be beneficial? On the other hand, if it didn't provide some survival advantage, why had the ...

Applied since the 1930s to accelerate the process of developing and selecting new valuable agronomic traits, mutation breeding uses a plant’s own genetic make-up, mimicking the natural process of ...

A new study led by Yale geneticists provides a long-needed tool to determine which mutations in the mitochondrial genome ...

Splice kits are used to establish a connection between two cables. They can come in many configurations, depending on the type of wire or cable being joined. Cable splicing is used to create one cable ...