The detection of physical forces is one of the most complex challenges facing science. Considered to play a decisive role in many biological processes, the chemical tools to visualize the physical ...

Mechanical intercellular forces determine the fate of extruding cells Cells within epithelial monolayers exert forces on their neighbors, which can trigger cell detachment and subsequent elimination.

In a basic model of friction, the magnitude of this force depends on two things: the types of materials interacting and the force with which they're pushed together.

Physical signals as fate deciders: How mechanical forces extrude cells from tissues Date: January 9, 2025 Source: Max Planck Institute for the Science of Light Summary: Epithelial tissues are in ...