On one strand — the “leading strand” — the polymerase can move continuously, leaving a trail of new double-stranded DNA behind it. But on the other, “lagging strand,” the polymerase has to move in ...

Thus, at any given time the lagging-strand polymerase could be moving faster than the leading-strand polymerase and vice-versa. To prevent the accumulation of unreplicated gaps in the nascent DNA, ...

First Look: DNA Replication For the first time ever, scientists have captured a single DNA molecule replicating on video — and it's changing the way we think about the entire process.

As for the lagging-strand, DNA synthesis should not have a problem. It could start the last Okazaki fragment somewhere along the 3' overhang.

This distinction represents a key difference between the functions of the leading strand clamp loader (CTF18-RFC) and the lagging strand clamp loader (RFC) and illuminates an important aspect of ...

To study DNA replication in vitro, Yeeles assembled replisomes with Saccharomyces cerevisiae proteins capable of performing complete leading- and lagging-strand replication.

The scientists determined that Mrc1 and Mcm2 form a co-chaperone complex, ensuring distribution of histones to the lagging strand during DNA replication.

As for the lagging-strand, DNA synthesis should not have a problem. It could start the last Okazaki fragment somewhere along the 3’ overhang.