A RIKEN researcher and his colleague have identified how genes are expressed in fish embryos when they first start using ...

The development of blood from stem cell to fully formed blood cell follows a genetically determined program. When it works properly, blood formation stops when it reaches maturity. But when it doesn't ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

Defying conventional epigenomic wisdom, the non-conventional polycomb (PRC)1 variant paradoxically overwhelms the conventional PRC-mediated gene silencing in activated endothelial cells. By ...

An epigenetic factor that is essential for producing mature egg cells in mice has been identified by RIKEN researchers for the first time. This discovery could aid research into cases of infertility ...

DNA's packaging can be just as important and intricate as the information in the DNA itself. A "histone code" is thought to lie behind the pattern of chemical modifications on histones, the spool-like ...

Shhh! Is silence conducive to learning and memory? Perhaps. But before you pack for the Buddhist temple, we’re talking gene silencing here, and only certain genes. In the March 10 Journal of ...

Epigenetic silencing in mammals involves DNA methylation and posttranslational modifications of core histones. Here we show that the H1 linker histone plays a key role in regulating both DNA ...

The spectrum of histone modifications at a given locus is a critical determinant for the correct output of gene expression. In Arabidopsis (Arabidopsis thaliana), many studies have examined the ...

Chromatin Immunoprecipitation Seqencing (ChIP-Seq) is a powerful tool that enables researchers to investigate and understand protein−DNA interactions and the influence these have on gene expression ...