Treatment with a simple chemical restores DNA repair to aging mice.

The findings — that DNA-damaging chemicals fail to induce mutations in mitochondria even when they cause expected DNA damage — upend conventional wisdom, and raise many new questions.

The results showed that the chemical could break up DNA strands, which could potentially lead to mutations or other cellular damage.

Then they determined where the metabolite attached to guanosines using single-nucleotide-resolution DNA mapping. While there was a dose-dependent relationship between exposure and DNA damage, the ...

A new chemical tool developed at UC Riverside interrupts that process, helping preserve DNA before the damage leads to disease.

In melanoma, we've now shown that damage from sunlight primes the DNA by creating 'premutations' that then give way to full mutations during DNA replication." Gerd Pfeifer, Ph.D., VAI professor ...

Mutations drive evolution. Subtle changes in the pairing of the chemical letters of DNA--adenine, cytosine, guanine and thymine--produce new cells with different traits than their ancestors. The ...