Telomerase was only preventing this from happening at the leading strand and Hiro’s data suggested that CST–Polα-primase fixed the second end-replication problem, that of the lagging strand.

The ‘leading’ strand is synthesized continuously, whereas the ‘lagging’ strand is synthesized in discontinuous sections that are subsequently joined together.

This enzyme can work only in the 5' to 3' direction, so it replicates the leading strand continuously. Lagging-strand replication is discontinuous, with short Okazaki fragments being formed and ...

Stop and Go Instead, the progress of the “lagging strand” polymerase looks a lot like stop and go traffic, stopping unpredictably and starting up again at random speeds that can vary tenfold.

This distinction represents a key difference between the functions of the leading strand clamp loader (CTF18-RFC) and the lagging strand clamp loader (RFC) and illuminates an important aspect of ...

Instead, the progress of the “lagging strand” polymerase looks a lot like stop and go traffic, stopping unpredictably and starting up again at random speeds that can vary tenfold.

This distinction represents a key difference between the functions of the leading strand clamp loader (CTF18-RFC) and the lagging strand clamp loader (RFC) and illuminates an important aspect of ...