DNA damage can accumulate in cells over time. And when that damage becomes excessive, or happens to certain important regions of the genome that contain specific genes, cancer can arise from that DNA ...

Scientists have mapped the activity of repair proteins in individual human cells. The study demonstrates how these proteins collaborate in so-called “hubs” to repair DNA damage.

DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

Novel map depicts the human body’s system for addressing and repairing DNA damage—a cause and consequence of many diseases.