Scientists had a molecule's eye view of the human cell's DNA repair kit as it assembled on a double-strand break to link together the broken ends. Double-strand breaks are ruptures that cut ...

DNA double-strand breaks (DSBs) are one of the most deleterious types of DNA lesions, which can result in mutagenic events or cell death if left unrepaired or repaired inappropriately.

In mammalian cells, DNA double-strand breaks (DSBs) are repaired predominantly by the non-homologous end joining (NHEJ) pathway, which includes subpathways that can repair different DNA-end ...

A new bioluminescent reporter that tracks DNA double stranded break repair in cells has been developed by researchers from Massachusetts General Hospital and the Academia Sinica in Taiwan.

A new research paper was published in Aging's Volume 15, Issue 19, entitled, “Reduction of double-strand DNA break repair exacerbates vascular aging.” ...

"These findings answer fundamental questions about DNA double-strand break repair," says Robb Krumlauf, Ph.D., Scientific Director of the Stowers Institute.

A deficiency in two of these repair proteins, ATM and NBS1, leads to defects in double-strand break repair by disrupting the signaling processes triggered by the break.