In higher eukaryotes, there are at least two pathways for DSB repair: homologous recombination (HR) and non-homologous end joining.

PURPOSEPoly ADP-ribose polymerase inhibitors (PARPi) are used for patients with advanced prostate cancer bearing alterations in homologous recombination repair (HRR) genes. We sought to characterize ...

Scientists have discovered that the RecA family recombinases function as a new type of rotary motor proteins to repair DNA damages. Homologous recombination (HR) is a mechanism that repairs ...

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Researchers unravel key steps in the process of homologous recombination DNA repair, providing potential new avenues for cancer research.

To test the contribution of homologous recombinational repair (HRR) in repairing DNA damage sites induced by high-energy iron ions, we used (1) HRR-deficient rodent cells carrying a deletion in the ...

Tokyo, Japan – Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by ...

Homologous recombination is a key process for maintaining genome integrity and diversity. In eukaryotes, the nucleosome structure of chromatin inhibits the progression of homologous recombination. The ...

Next-generation PARP inhibitor demonstrates clinical benefit in patients with homologous recombination repair-deficient breast cancer ...

Direct Evidence for a Role for BRCA1 in Homologous Recombination Sensitivity to ionizing radiation is compelling evidence that BRCA1- and BRCA2- deficient cells are defective in repair of DSBs.