Replication of the lagging strand of DNA involves the production of discrete Okazaki fragments that are ligated together. Nucleosome assembly is coupled to replication, and until now it was not ...

This new data revealed something unexpected: not only was the leading strand in need of help—he found evidence that the end of the lagging strand could also not be synthesized by the replisome.

Stop and Go Instead, the progress of the “lagging strand” polymerase looks a lot like stop and go traffic, stopping unpredictably and starting up again at random speeds that can vary tenfold.