Normally for the lagging strand, DNA synthesis is unhindered, and the replisome starts synthesizing the last Okazaki fragments along the 3’ overhang that are later stitched together to prevent ...

As for the lagging-strand, DNA synthesis should not have a problem. It could start the last Okazaki fragment somewhere along the 3’ overhang.

As the leading strand T7 replisome does not pause during primer synthesis, this cannot explain why the leading and lagging strands are synthesized at the same rate. However, the authors found that ...

As primer synthesis proceeds, DNA primase acts as a molecular brake on the leading-strand polymerase during slow enzymatic steps on the lagging strand.