This enzyme can work only in the 5' to 3' direction, so it replicates the leading strand continuously. Lagging-strand replication is discontinuous, with short Okazaki fragments being formed and ...

A major finding was that the template damage was only a transitory block to replication fork progression. Template unwinding and lagging-strand synthesis continued at a reduced rate downstream of the ...

The polymerase on the “leading strand” can easily work at a continuous pace, but the polymerase on the “lagging strand” cannot.

This distinction represents a key difference between the functions of the leading strand clamp loader (CTF18-RFC) and the lagging strand clamp loader (RFC) and illuminates an important aspect of ...

Their findings, published recently in Nature, demonstrated that while telomerase addressed the end-replication problem at the leading strand, another complex worked in tandem at the lagging strand. 3 ...

The polymerase on the “leading strand” can easily work at a continuous pace, but the polymerase on the “lagging strand” cannot.