This project has reached full capacity for the current term. Please check back next semester for updates. Errors in DNA replication occur at the replication fork, leading to misincorporation events, ...

Pancreatic ductal adenocarcinoma is similarly treated with pyrimidine analogs, yet the predictive value of mismatch repair status for response to these agents has not been examined in this malignancy.

Among patients with mismatch repair–deficient (dMMR), locally advanced rectal cancer, neoadjuvant checkpoint blockade eliminated the need for surgery in a high proportion of patients. Whether ...

Patients with mismatch repair-deficient endometrial cancer have longer overall survival than those with mismatch repair-proficient tumour, a UK study reports.

Conclusions Mismatch repair–deficient, locally advanced rectal cancer was highly sensitive to single-agent PD-1 blockade. Longer follow-up is needed to assess the duration of response.

Jemperli is the first and only approved programmed death receptor-1 (PD-1) immunotherapy for the second-line treatment of ...