This project has reached full capacity for the current term. Please check back next semester for updates. Errors in DNA replication occur at the replication fork, leading to misincorporation events, ...

The newly published study takes a hard look at the underlying mechanisms for the DNA mismatch repair (MMR) pathway—which helps maintain genomic fidelity by more than 1000-fold.

Genetic variations in DNA mismatch repair are associated with tumor response to preoperative therapy, tumor respectability, and overall survival of patients with pancreatic cancer treated with ...

Pancreatic ductal adenocarcinoma is similarly treated with pyrimidine analogs, yet the predictive value of mismatch repair status for response to these agents has not been examined in this malignancy.

Among patients with mismatch repair–deficient (dMMR), locally advanced rectal cancer, neoadjuvant checkpoint blockade eliminated the need for surgery in a high proportion of patients. Whether ...

Nivolumab showed promising activity in DNA mismatch repair (MMR)-deficient tumors that had complete loss of the tumor suppressor proteins MLH1 or MSH2.

TPS839Background: Cancers deficient in DNA mismatch repair (dMMR) are highly immunogenic tumors exhibiting high rates of response to immune checkpoint inhibitors targeting the programmed cell death-1 ...

Conclusions Mismatch repair–deficient, locally advanced rectal cancer was highly sensitive to single-agent PD-1 blockade. Longer follow-up is needed to assess the duration of response.

Patients with mismatch repair-deficient endometrial cancer have longer overall survival than those with mismatch repair-proficient tumour, a UK study reports.

DNA mismatch repair (MMR) is critical in maintaining genomic stability and may modulate the cellular response to gemcitabine. We hypothesized that genetic variations in MMR may affect the clinical ...

We conclude that defective DNA mismatch repair does not play a role in the pathogenesis of low-grade appendiceal mucinous neoplasms.