Mismatch Repair system protein deficiency as a factor of resistance to chemo-radiotherapy treatment in patients with locally advanced rectal adenocarcinoma and its influence on disease-free survival.

The DNA mismatch repair system is integral to maintaining genomic stability, and mismatch repair deficiency is observed in many malignancies. 11 Mismatch repair deficiency often has hereditary ...

3579 Background: Colorectal cancer with deficient mismatch repair system (dMMR) has been associated with favorable prognosis in early-stage disease. The influence of dMMR on response to chemotherapy ...

A central mystery is how the mismatch repair system is flexible enough to recognize such a triggering strand break on either side of the mismatch along the DNA strand, said Modrich.

"We have leveraged the volume of the largest gastrointestinal pathology group in the U.S. to study the prevalence of mismatch repair deficiency in colorectal adenocarcinoma,” said lead author ...

The team also analyzed DNA sequences from two separate groups of patients with mismatch repair deficient tumors treated with anti-PD-1 immunotherapy.

This protein machinery—the DNA mismatch repair system—reversed the prime editor’s changes if it noticed the rewriting. By adding in silent mutations near the edits they made to F508del, Liu’s team ...

Promega OncoMate™ MSI Dx Analysis System is cleared by the FDA as an IVD to determine microsatellite instability status in colorectal cancer tumors.