Despite the missed opportunity to gain ground, the 49ers improved to 10-4 and remain firmly in the playoff hunt with three games left on the schedule. San Francisco will travel to face the Indianapolis Colts in Week 16 before closing the regular season with home games against the Chicago Bears and the Seahawks.

If these two things happen, the 49ers would finish 13-4 and win the NFC West over a 13-4 Rams team based on the division record tiebreaker. If the Seahawks also finish 13-4 in this scenario, the 49ers would have swept them, so they'd win any tiebreaker with Seattle. At 7-to-1 odds to win the NFC West, the 49ers feel like a steal.

If Seattle wins the second matchup between the teams on Thursday night at Lumen Field, the Seahawks officially clinch a spot in the playoffs. The Seahawks also will clinch if the Lions either tie or lose against the Pittsburgh Steelers on Sunday.

The Rams (+350) and Seahawks (+700) remain the top two teams in BetMGM’s Super Bowl odds with Week 15 victories — setting up a major NFC West showdown on Thursday night.

The 49ers’ special teams has flipped from a major liability to a historic strength in 2025 under Brant Boyer, changing their playoff outlook.

The San Francisco 49ers beat the Tennessee Titans on Sunday. How did their performance affect their standing heading into Week 16?

Jason Logan breaks down his early 49ers vs. Colts predictions and explains why there's value backing the home underdog. Free NFL picks for December 22.

The biggest winner in the NFC besides the Seahawks is the 49ers. Besides finally having another NFC contender share in their injury misery, San Francisco's surprising path to the top seed in the NFC just got intriguing. The 49ers are 10-4 and will be the top seed in the conference if they win out and the Seahawks beat the Rams on Thursday.