DNA damage can accumulate in cells over time. And when that damage becomes excessive, or happens to certain important regions of the genome that contain specific genes, cancer can arise from that DNA ...

According to the scientists, knowledge about the role of NEAT1 methylation in the recognition and repair of DNA damage could open up new therapeutic options for tumors with high NEAT1 expression.

Recognition and repair of damaged DNA is essential for genomic stability in all living cells. There are several pathways of DNA repair and, for some types of damage, repair pathways might compete ...

How chromatin responds to transcription-blocking DNA lesions is unclear. This study reveals that RNA polymerase II (RNAPII) ...

Could DNA be glycosylated? A new study published in Engineering explores this intriguing question, suggesting that DNA might undergo glycosylation, a process that could revolutionize our understanding ...

“We investigated the dynamic protein–DNA interactions during the damage recognition step using single-molecule fluorescence microscopy,” the authors wrote.

Aging is accompanied by genetic changes — gene-expression shifts and pathways go haywire. Why this happens has been poorly understood. New findings provide an answer.

A new study focused on multiple myeloma, the second most common blood cancer, may lead to better ways to group patients by ...

It turns out that many genes involved in the DNA damage response encode constituents of the homologous recombination pathway, and defects in these genes result in predisposition to cancer and ...

DNA aptamers are powerful molecular tools in biosensing, bioimaging and therapeutics. However, a limited understanding of ...

Researchers identified a new mechanism in the DNA damage response involving the long non-coding RNA NEAT1. Increased NEAT1 levels and methylation enhance the recognition of DNA damage.