Homologous recombination is a key process for maintaining genome integrity and diversity. In eukaryotes, the nucleosome structure of chromatin inhibits the progression of homologous recombination. The ...

Li Han, Weifeng Mao, Kefei Yu, X-ray repair cross-complementing protein 1 (XRCC1) deficiency enhances class switch recombination and is permissive for alternative end joining, Proceedings of the ...

The transcription-independent function of p53 facilitates DNA repair and controls recombination. p53 facilitates base-excision repair (BER) mainly via association with BER components. For example ...

Scientists have discovered that the RecA family recombinases function as a new type of rotary motor proteins to repair DNA damages. Homologous recombination (HR) is a mechanism that repairs ...

Tokyo, Japan – Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by ...

Researchers unravel key steps in the process of homologous recombination DNA repair, providing potential new avenues for cancer research.

Homologous recombination repair mutations have been identified in up to 25% of patients with metastatic disease. This study shows that early intervention with a PARP inhibitor may improve outcomes.