A critical step in increasing the precision of genome engineering was the discovery that an induced gene-specific double-strand break could stimulate homologous recombination at the break site by ...

In other words, inducing a double-strand break at a specific chromosomal location promoted high-frequency homologous recombination.

Dr. Daley is first author of research, published June 18 in the journal Nature Communications, that sheds light on a double-strand break repair process called homologous recombination.

Richardson C, Moynahan ME, Jasin M. 1998 Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations. Genes Dev. 1998;12:3831-3842. Elliott B, Richardson C, ...

DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination. Molecular Cell, 2017; DOI: 10.1016/j.molcel.2016.12.016 ...

A double-strand break (DSB) is a type of DNA damage where both strands of the DNA helix are cut or broken at the same location, causing a complete discontinuity in the DNA molecule. Unrepaired or ...

What's in a blob? The key to proper pairing of X and Y, they discovered, is a repeated sequence of DNA in the PAR that attracts several double-strand break-related proteins to this region.

Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a dangling ...

Despite its relative simplicity, the method presented allows both the quantitative and qualitative description of radiation-induced DNA fragmentation and subsequent rejoining of double-stranded DNA ...

Understanding the mechanism and regulation of recombination is thus critical for understanding how meiotic errors affect human fertility and child development. Meiotic recombination initiates with DNA ...

Tumors with compromised ability to repair double-strand DNA breaks by homologous recombination, including those with defects in BRCA1 and BRCA2, are highly sensitive to blockade of the repair of DNA ...