Under Kyle Shanahan, the San Francisco 49ers have tended to either dominate as NFC contenders or succumb to a rash of ...

The 49ers face major setbacks with Brock Purdy sidelined by turf toe and George Kittle on IR, leaving Mac Jones to keep San ...

A banged up and shorthanded San Francisco 49ers (1-0) squad hits the gridiron Sunday in New Orleans against the Saints (0-1).

The San Francisco 49ers have a nine-time Pro Bowler in the building ready to take over for George Kittle. Wait, what?

It's only been one week into the 2025 NFL regular season and the injury bug has taken a major chunk out of the San Francisco ...