This important work advances our understanding of DNA methylation and its consequences for susceptibility to DNA damage. This work presents evidence that DNA methylation can accentuate the genomic ...

StitchR, a new gene therapy technique, delivers large genes in two parts to treat muscular dystrophies by restoring critical proteins in animal models.

Researchers reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected 'second jobs' within the nucleus, orchestrating critical ...

They discovered that DNA packaging sends signals through an unusual pathway, affecting the cell's ability to divide ... Her group investigates chromatin dynamics during DNA replication and repair. The ...

The study is the first to demonstrate that the nucleus relies on metabolic pathways to maintain the integrity and ... IMPDH2 relocates to the nucleus of TNBC cells to assist in DNA repair processes.

Researchers from the Mattiroli group have found that the way DNA is packaged in cells can directly impact how fast DNA itself is copied during cell division. They discovered that DNA packaging sends ...

Bacteria frequently encounter adverse environmental conditions, such as nutrient scarcity and antibiotic exposure, which can induce DNA damage ...

Red arrows indicate the DNA repair pathways that are known to aid bacterial survival as persisters and gamblers in the ...