The most coveted running backs in fantasy drafts all lived up to their high expectations in the season's first week. Who's poised to do so again?

Here is a first look at the broadcast map for the Pittsburgh Steelers’ Week 2 matchup with the Seattle Seahawks.

San Francisco 49ers quarterback Brock Purdy is a “long shot” to play on Sunday against the New Orleans Saints and could miss ...

This week, CMC isn't viewed as an injury concern. That's the rest of the 49ers who are hurting. Brock Purdy is a big doubt to ...

The best thing about this season for Christian McCaffrey is it isn’t last season. The running back and the 49ers downplayed a ...

San Francisco 49ers running back Christian McCaffrey (calf, rest) did not participate in practice on Wednesday. This ...

Caesars Superdome is the site where the New Orleans Saints (0-1) will try to defeat the San Francisco 49ers (1-0) on Sunday.

Head coach Kyle Shanahan shared the latest on QB Brock Purdy, RB Christian McCaffrey, and other player injuries, explained the team's move to bring in K Eddy Piñeiro, and previewed Week 2 vs. New ...

There was plenty of uncertainty surrounding Christian McCaffrey's availability heading into Week 1 against the Seattle Seahawks. The San Francisco 49ers listed the star running back as "questionable," ...

Purdy's injury doesn't make things any better for the 49ers, as George Kittle will miss some time after suffering a hamstring ...

The Seattle Seahawks entered the regular season without a traditional nose tackle on their active 53-man roster. Quinton ...

Granted, the 49ers want to get McCaffrey the football. However, they have to be careful not to overwork him. If he were to get hurt, the offense would be in major trouble, especially without Kittle on ...