This article was originally published on www.si.com/nfl/49ers as Why George Kittle's hamstring injury is a major concern for the 49ers. San Francisco 49ers tight end George Kittle has now been placed on IR.

A brutal injury update has come out today on star tight end George Kittle and the San Francisco 49ers.

San Francisco 49ers place-kicker Jake Moody (4) attempts to kick a field goal that was incomplete during the first half of an NFL football game against the Seattle Seahawks, Sunday, Sept. 7, 2025, in Seattle. Credit: AP/Lindsey Wasson

San Francisco 49ers tight end George Kittle was designated to IR after suffering a hamstring injury in Week 1.

The San Francisco 49ers will place tight end George Kittle on injured reserve due to his hamstring injury, prompting a mandatory absence of at least four games.

The San Francisco 49ers have placed tight end George Kittle on the IR after the star tight end suffered a hamstring injury in the team's season opener against the Seattle Seahawks. Last season, the 49ers were decimated by injury. It appears that is going to be the case in 2025 as well.

The San Francisco 49ers will have to get through the next four weeks of their schedule without star tight end George Kittle after placing the All-Pro on injured reserve with a hamstring injury, according to CBS Sports NFL insider Jonathan Jones .

San Francisco 49ers tight end George Kittle was placed on injured reserve Tuesday and will miss at least the next four games.

But, San Francisco didn't get out without some bumps and bruises. Star 49ers tight end George Kittle exited with a hamstring injury and wide receiver Jauan Jennings departed with a shoulder injury. 49ers head coach Kyle Shanahan didn't have an update on the pair's injury statuses following the win.