Pathology Outlines - Plasma cell myeloma (multiple myeloma)
Sep 27, 2023 · Essential features. Diagnosis requires synthesis of clinical, laboratory, radiologic and histologic findings. Assessment of serum or urine M protein, clonal plasma cells in bone marrow and presence of end organ damage related to …
Histology, Plasma Cells - StatPearls - NCBI Bookshelf
Dec 30, 2022 · Plasma cells are differentiated B-lymphocyte white blood cells capable of secreting immunoglobulin or antibodies. They play a significant role in the adaptive immune response, being the main cells responsible for humoral immunity.
The morphology of myeloma cells changes with progression of …
Plasma cells found in bone marrow smears are characterised by extremely high diversity of morphology. We have attempted to determine whether the morphological characteristics of myeloma cells vary with the natural course of the disease.
Plasma cell morphology in multiple myeloma and related disorders
Normal and reactive plasma cells (PC) are easy to ascertain on human bone marrow films, due to their small mature-appearing nucleus and large cytoplasm, the latter usually deep blue after Giemsa staining. Cytoplasm is filled with long strands of rough endoplasmic reticulum and one large Golgi appara …
The many faces of plasma cell neoplasms: morphological and
Peripheral blood smear shows numerous plasma cells with a monocytoid morphology (irregular, lobulated to flower-like nuclei with moderately condensed chromatin, abundant basophilic cytoplasm with cytoplasmic blebs and vacuoles).
Morphologic and Immunohistochemical Evaluation of Plasma Cell …
Dec 31, 2016 · Plasma cell myeloma (PCM) is a bone marrow-based neoplasm, the diagnosis of which is straightforward in most cases. The presence of marked cytologic pleomorphism and extramedullary involvement, for example, can make the diagnosis of myeloma a difficult one in some instances.
Plasma cell morphology in multiple myeloma and related disorders
Jun 1, 2015 · Plasma cells (PC) are terminally differentiated lymphoid B cells that are located within the BM and within the medulla of lymph nodes. Their implication in the immune process is due to the immunoglobulin (Ig) they synthesize that acts as an antibody against antigens.
Plasma cell myeloma: role of histopathology, …
Mar 9, 2021 · – Diagnosis and risk stratification of plasma cell myeloma require clinical, histologic, immunophenotypic, radiographic, serologic, and genetic data. – Myeloma plasma cells demonstrate diverse morphology ranging from mature, normal-appearing plasma cells to immature-appearing, plasmablast-like cells.
Multiple Myeloma - Multiple Myeloma - Merck Manual Professional Edition
Malignant plasma cells produce monoclonal immunoglobulin and invade and destroy bone. Expanding plasmacytomas and cytokine secretion cause multiple, discrete, osteolytic lesions (usually in the pelvis, spine, ribs, and skull) and diffuse osteoporosis; pain, fractures, and hypercalcemia are common.
Bone marrow morphologic features, MyPRS, and gene …
Aug 2, 2019 · For the first time we show that high plasma cell volume, diffuse sheet growth pattern, immature cell morphology, high mitotic index, and increased reticulin fibrosis, significantly correlates...
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