Progressive multifocal leukoencephalopathy - Radiopaedia.org
Jun 13, 2024 · Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease which results from the reactivation of John Cunningham virus (JC virus) infecting oligodendrocytes in patients with compromised immune systems.
Progressive Multifocal Leukoencephalopathy (PML)
Provisional diagnosis of PML is made by contrast-enhanced MRI, which shows single or multiple white matter lesions on T2-weighted images. A contrast agent enhances, usually faintly and peripherally, 5 to 15% of lesions.
Progressive Multifocal Leukoencephalopathy - StatPearls - NCBI Bookshelf
Jul 10, 2023 · In PML-IRIS, patients present with worsening neurological status after initiating ART, or after reducing immunosuppressive therapy, inflammatory changes follow and would reveal contrast enhancement, edema, and mass effect on MRI imaging. Similiar MRI findings are noticed in patients who develop PML following natalizumab therapy.
Imaging in Progressive Multifocal Leukoencephalopathy (PML)
The characteristics of PML, as seen on magnetic resonance imaging (MRI) and computed tomography (CT) scans, are demonstrated below. T2-weighted MRI in a patient infected with HIV demonstrates a...
PML Diagnosis & Management Fact Sheet - Cleveland Clinic
PML should be suspected in MS patients with new characteristic lesions on MRI or sub-acute (evolving over weeks or months) progressive neurologic symptoms in the setting of immunosuppressive medications known to increase the risk of PML.
Progressive multifocal leukoencephalopathy (PML ... - UpToDate
Jul 26, 2024 · Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system. The epidemiology, clinical features, and diagnosis of PML will be reviewed here. The treatment of PML is discussed separately.
neuroradiology of progressive multifocal leukoencephalopathy: …
Nov 16, 2021 · Imaging findings of PML on multisequence MRI. Axial brain MRI images of a patient presenting with PML lesions in bilateral occipital lobes, primarily in the subcortical white matter and adjacent cortical grey matter.
Progressive multifocal leukoencephalopathy lesion and brain …
Nov 11, 2020 · Magnetic resonance imaging (MRI) is considered the gold standard method for the identification and monitoring of PML lesions in vivo. On MRI, PML lesions appear as multifocal, patchy, and/or confluent areas of hyperintensity on T2-weighted sequences, often with corresponding hypointensity on T1-weighted images ( Tan and Koralnik, 2010 ).
Radiological abnormalities in progressive multifocal ...
Sep 1, 2023 · Brain MRI, particularly T2-weighted imaging, monitors PML progression during treatment. A recent study used T2WI to quantify lesion volume using deep learning. Automated brain atrophy and lesion segmentation in PML hold clinical value and promise for standardized MRI measures in clinical trials of targeted therapies ( Al-Louzi et al., 2020 ).
Image: Progressive Multifocal Leukoencephalopathy - MSD …
Progressive Multifocal Leukoencephalopathy / This T2-weighted MRI image shows multiple changes in white matter. Image provided by John E. Greenlee, MD. In these topics. Progressive Multifocal Leukoencephalopathy (PML)