Rational design - Wikipedia
In chemical biology and biomolecular engineering, rational design (RD) is an umbrella term which invites the strategy of creating new molecules with a certain functionality, based upon the ability to predict how the molecule's structure (specifically derived from motifs) will affect its behavior through physical models.
Rational Design - an overview | ScienceDirect Topics
Identify rational design rules for manufacturing and oral processing. • Rational design is based on fundamental physics and physicochemical properties. • Current research only partially addresses these aspects of design.
Rational Design - SpringerLink
Mar 31, 2017 · In this chapter, we will examine Simon’s general theory of design and his depiction of good design as rational design. Then, we will explore how this perspective applies in practice. It will be helpful to begin with a case study.
Introduction to Directed Evolution and Rational Design as Protein ...
Jan 6, 2023 · A panoramic view of directed enzyme evolution and rational enzyme design is given in this chapter, including the methods, aims, and historical developments up to the current status. The relative merits of the approaches are discussed.
Towards rational material design | Nature Materials
Oct 1, 2003 · Rational design is an oft-touted dream in materials science. The discovery of two new classes of photonic bandgap crystals may herald the systematic mathematical design of new materials.
Protein engineering strategies for rational immunogen design
Dec 17, 2021 · The following sections focus on three general approaches of immunogen design. We discuss recent developments in strategies to (1) magnify the overall humoral response, (2) prevent or reduce the...
Rational design: best route for synthetic biology? - Wyss Institute
May 22, 2014 · A healthy debate exists in science about the best way to engineer new biological systems that can clean water, generate green energy solutions, treat diseases, and more. In Nature Wyss Institute Core Faculty member Pamela Silver and Senior Staff Scientist Jeffrey Way argue that a rational design approach is the best way to go...
Rational design of proteins that exchange on functional timescales - Nature
Oct 23, 2017 · Rational design of protein dynamics requires the prediction of sequences that can adopt all conformations needed for exchange between predefined states.
Rational and Semirational Protein Design | SpringerLink
Oct 31, 2017 · This mini review gives an overview over different design approaches and methodologies applied in rational and semirational enzyme engineering. The underlying principles for engineering novel activities, enantioselectivity, substrate specificity, stability, and pH optimum are summarized. Download protocol PDF.
Rational and Semirational Protein Design - PMC - National …
This mini review gives an overview over different design approaches and methodologies applied in rational and semirational enzyme engineering. The underlying principles for engineering novel activities, enantioselectivity, substrate specificity, stability, and pH optimum are summarized.