Genetic recombination lecture 1 | homologous recombination
43:57
YouTubeShomu's Biology
Genetic recombination lecture 1 | homologous recombination
This lecture about genetic recombination explains about the homologous recombination process and also the role of homologous recombination in double stranded break repair of DNA. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials ...
103.6K viewsJul 31, 2015
Homologous Recombination Animation
Mechanism of Recombination, 3D animation with with basic narration
Mechanism of Recombination, 3D animation with with basic narration
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PolyADP-ribose polymerase (PARP) plays a key role in the repair of DNA single-strand breaks. In the presence of the PARP inhibitor olaparib, single-strand breaks accumulate. When a replication fork encounters a single-strand break, it converts it to a double-strand break, which in normal cells is then repaired by homologous recombination. In cells defective for homologous recombination, however, inhibition of PARP triggers cell death. Patients who have only one functional copy of the Brcal gene,
PolyADP-ribose polymerase (PARP) plays a key role in the repair of DNA single-strand breaks. In the presence of the PARP inhibitor olaparib, single-strand breaks accumulate. When a replication fork encounters a single-strand break, it converts it to a double-strand break, which in normal cells is then repaired by homologous recombination. In cells defective for homologous recombination, however, inhibition of PARP triggers cell death. Patients who have only one functional copy of the Brcal gene,
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