Nrf2 pathway in detail. The Nrf2 pathway is essentially a network of genes and proteins that govern the body’s antioxidant response. When the body is exposed to oxidative stress or toxins, the Nrf2 pathway is activated, leading to the expression of various genes that help to neutralize these harmful agents. At the cellular level, the Nrf2 pathway works by binding to specific DNA sequences called antioxidant response elements (AREs). When activated, Nrf2 binds to AREs and initiates the transcript
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Here’s why the Nrf2 pathway is so important when dealing with cancer: 1. Antioxidant Defense: Nrf2 activates genes that produce antioxidants, which neutralize harmful free radicals and reduce cellular damage that can lead to cancer. 2. Protecting Healthy Cells: Nrf2 protects healthy cells from oxidative stress, but in some cancers, overactive Nrf2 can help cancer cells survive under stressful conditions. 3. Inflammation Regulation: Nrf2 controls inflammation by inhibiting pro-inflammatory pathwa
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