Plaque formation is the buildup of deposits, typically a sticky film of bacteria and food particles on teeth (dental plaque) or fatty cholesterol and other substances in arteries (atherosclerotic plaque), both leading to serious health issues like tooth decay, gum disease, heart attacks, and strokes. Dental plaque forms from oral bacteria and sugary foods, while atherosclerotic plaque results from high cholesterol, high blood pressure, smoking, and diabetes. Dental Plaque Formation Initial Colon